Risk of breast cancer in women treated with ovarian stimulation drugs for infertility: a systematic review and meta-analysis

ObjectiveTo evaluate the evidence addressing association between use of ovarian stimulation drugs and risk breast cancer.DesignSystematic review meta-analysis.SettingNot applicable.Patient(s)Women without any previous history cancer undergoing stimulation.Intervention(s)Electronic databases were searched from 1990 until January 2020. All cohort studies reporting new incidences in infertile women using stimulating included. Treated (exposed) compared with unexposed general population as controls.Main Outcome Measure(s)New diagnosis within an after exposure to drugs.Result(s)Overall, quality was very low because serious bias indirectness (nonrandomized studies). There no significant increase among treated drug for infertility that controls (pooled odds ratio 1.03, 95% Confidence interval 0.86 1.23, 20 studies, I2 = 88.41%, evidence). Furthermore, found clomiphene citrate or gonadotropins, alone combination.Conclusion(s)The current study gonadotropins not associated increased cancer. To Systematic meta-analysis. Not applicable. Women stimulation. Electronic controls. New drugs. Overall, combination. The